Biochemistry
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Temperature and pH effects on the formation of cyclodextrin-fluorouracil and cyclodextrin-uracil complexes.
(Wheaton College (MA)., 2018)This study analyses the effects of pH and temperature on cyclodextrin-fluorouracil and cyclodextrin-uracil complexes. Fluorouracil is a chemotherapy drug given in high dosages leading to severe adverse effects. To reduce ... -
Zebrafish aging is a determining factor in breast cancer cell xenotransplant efficacy.
(Wheaton College (Norton, Mass.), 2017)Breast cancer is the most commonly diagnosed cancer in women and a leading cause of cancer death in women. Studies that examine the effects of certain environmental factors, which can mimic estrogen function and thus mediate ... -
Cilia dynamics in cardiac regeneration in zebrafish (danio rerio).
(Wheaton College (Norton, Mass.), 2017)Ischemic injury in the human heart can lead to massive cell death and inelastic scar tissue formation, resulting in diminished cardiac function. In contrast, zebrafish (Danio rerio) can regenerate injured heart tissue ... -
Cilia abundance in regenerating zebrafish cardiac tissue and their potential relation to cell signaling pathways.
(Wheaton College (Norton, Mass.), 2016)Heart disease is one of the leading causes of death worldwide. After injury caused by trauma such as a myocardial infarction, human cardiac tissue is unable to heal without scaring. Damage to adult human heart tissue results ... -
The role of methylmercury on thioredoxin reductase activity in breast cancer cells.
(Wheaton College (Norton, Mass.), 2016)Metalloestrogens are small ionic metals and metalloids that activate the estrogen receptor (ER) in a manner similar to estrogen. When metalloestrogens bind to the ER, there is an increase in the expression of estrogen-related ... -
Method development for detecting metals in human nails and hair using an indigo-spiropyran sensor.
(Wheaton College (Norton, Mass.), 2015)The main goal of this study was to design a nitrospiropyran-indigo based sensor for detecting metal concentration in human samples. The dye indigo and its derivatives form a complex with different metal ions such as Cu²⁺ ... -
Effects of methylmercury on breast cancer cells.
(Wheaton College (Norton, Mass.), 2015)Metalloestrogens are small ionic metals that activate the estrogen receptor (ER). Studies have shown that when metalloestrogens bind to the ER there is an increase in the transcription and expression of estrogen-related ... -
Effects of MeHg on ROS regulation in neutrophil cell culture
(Wheaton College (Norton, Mass.), 2014)"Methylmercury (MeHg) is an environmental toxin that targets the nervous system but can cause an array of effects on other systems as well. The main source of exposure is through fish consumption, because MeHg bioaccumulates ... -
Patterns of ciliary retraction in echinoid embryos.
(Wheaton College (Norton, Mass.), 2014)In this study sea urchin embryos were used to investigate how cilia are disassembled and to investigate the role that cilia play in cell division. A retraction mechanism was proposed in which the ciliary axoneme is entirely ... -
Synthesis of hydroxy acids using asymmetric hydrogenation in water.
(Wheaton College (Norton, Mass.), 2013-09-17)The purpose of this study was to develop a green chemistry synthesis of hydroxy acids from the starting material glyoxylic acid. Two reactions that were the primary focus of this study. The first was the Wittig-Horner ... -
Asymmetric hydrogenation of tyrosine analogues in water.
(Wheaton College (Norton, Mass.), 2013-09-13)"The purpose of this study was to investigate the feasibility of using water for the synthesis of tyrosine analogues through asymmetric hydrogenation reactions. A variety of α-enamide substrates, varying in R groups and ... -
Asymmetric hydrogenation of enamide esters in aqueous media.
(Wheaton College; Norton, Mass., 2011-11-23)The purpose of this research was to investigate the feasibility of using aqueous media for the synthesis of amino acid precursors through asymmetric hydrogenation reactions. Acetyl-protected enamide esters with a variety ...
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