Browsing Biochemistry by Title
Now showing items 3-18 of 18
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Cilia abundance in regenerating zebrafish cardiac tissue and their potential relation to cell signaling pathways.
(Wheaton College (Norton, Mass.), 2016)Heart disease is one of the leading causes of death worldwide. After injury caused by trauma such as a myocardial infarction, human cardiac tissue is unable to heal without scaring. Damage to adult human heart tissue results ... -
Cilia dynamics in cardiac regeneration in zebrafish (danio rerio).
(Wheaton College (Norton, Mass.), 2017)Ischemic injury in the human heart can lead to massive cell death and inelastic scar tissue formation, resulting in diminished cardiac function. In contrast, zebrafish (Danio rerio) can regenerate injured heart tissue ... -
The effects of HE4 on ovarian cancer progression in danio rerio embryos.
(Wheaton College (MA), 2019)Ovarian cancer is one of the most lethal cancers in the world. The high lethality is partially caused by the onset of metastasis during cancer progression. HE4 protein, a protein resides on human chromosome 20, is found ... -
Effects of MeHg on ROS regulation in neutrophil cell culture
(Wheaton College (Norton, Mass.), 2014)"Methylmercury (MeHg) is an environmental toxin that targets the nervous system but can cause an array of effects on other systems as well. The main source of exposure is through fish consumption, because MeHg bioaccumulates ... -
Effects of methylmercury on breast cancer cells.
(Wheaton College (Norton, Mass.), 2015)Metalloestrogens are small ionic metals that activate the estrogen receptor (ER). Studies have shown that when metalloestrogens bind to the ER there is an increase in the transcription and expression of estrogen-related ... -
Green methodologies for the synthesis of alcohols and esters widely used in the cosmetics industry.
(Wheaton College (MA), 2019)Three alcohols (1-phenylethanol, 3-octanol, and 3,3,5-trimethylcyclohexanol), and two esters (3,3,5-trimethylcyclohexanyl propanoate and 3,3,5-trimethylcyclohexanyl cyclopropanoate), with known applications in the cosmetics ... -
Investigation of ciliated cell types and ciliary gene expression during heart regeneration in zebrafish (Danio rerio)
(Wheaton College. (Norton, Mass.), 2021-05-16)Unlike the adult mammalian heart, the adult zebrafish (Danio rerio) heart can regenerate after injury. In a series of regenerative processes, the zebrafish can regenerate their hearts after up to 20% of their ventricle ... -
Method development for detecting metals in human nails and hair using an indigo-spiropyran sensor.
(Wheaton College (Norton, Mass.), 2015)The main goal of this study was to design a nitrospiropyran-indigo based sensor for detecting metal concentration in human samples. The dye indigo and its derivatives form a complex with different metal ions such as Cu²⁺ ... -
Patterns of ciliary retraction in echinoid embryos.
(Wheaton College (Norton, Mass.), 2014)In this study sea urchin embryos were used to investigate how cilia are disassembled and to investigate the role that cilia play in cell division. A retraction mechanism was proposed in which the ciliary axoneme is entirely ... -
The Relationship Between ACE2 and the ABO Blood Groups in SARS-CoV-2 Infection Rates
(Wheaton College. (Norton, Mass.), 2021-05-16)The COVID-19 pandemic is one of the most brutal pandemics mankind has had to endure. The novel coronavirus has taken the world by storm, with millions of deaths in just a year. Further research has indicated that the ... -
The Risk of SARS-CoV-2 Reinfection and the Limits of Inherent Immunity
(Wheaton College. (Norton, Mass), 2021-05-15)SARS-CoV-2 is the virus that causes the coronavirus disease 2019 (COVID-19) and is the cause of a global pandemic that has infected 155 million people worldwide as of May 2021.1 SARS-CoV-2 is an enveloped and spherical ... -
The role of methylmercury on thioredoxin reductase activity in breast cancer cells.
(Wheaton College (Norton, Mass.), 2016)Metalloestrogens are small ionic metals and metalloids that activate the estrogen receptor (ER) in a manner similar to estrogen. When metalloestrogens bind to the ER, there is an increase in the expression of estrogen-related ... -
Structural modification of a natural angiotensin converting enzyme inhibitor and the effect on activity.
(Wheaton College (MA), 2019)Hypertension is a leading risk factor for mortality that affects nearly a third of adult US residents, and it is primarily combatted through the use of angiotensin converting enzyme inhibitors (ACEIs). In addition to ACEIs ... -
Synthesis of hydroxy acids using asymmetric hydrogenation in water.
(Wheaton College (Norton, Mass.), 2013-09-17)The purpose of this study was to develop a green chemistry synthesis of hydroxy acids from the starting material glyoxylic acid. Two reactions that were the primary focus of this study. The first was the Wittig-Horner ... -
Temperature and pH effects on the formation of cyclodextrin-fluorouracil and cyclodextrin-uracil complexes.
(Wheaton College (MA)., 2018)This study analyses the effects of pH and temperature on cyclodextrin-fluorouracil and cyclodextrin-uracil complexes. Fluorouracil is a chemotherapy drug given in high dosages leading to severe adverse effects. To reduce ... -
Zebrafish aging is a determining factor in breast cancer cell xenotransplant efficacy.
(Wheaton College (Norton, Mass.), 2017)Breast cancer is the most commonly diagnosed cancer in women and a leading cause of cancer death in women. Studies that examine the effects of certain environmental factors, which can mimic estrogen function and thus mediate ...
