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dc.contributor.authorMoreira, Amy.
dc.date.accessioned2013-09-13T17:05:24Z
dc.date.available2013-09-13T17:05:24Z
dc.date.issued2013-09-13
dc.identifier.otherW Thesis 1428
dc.identifier.urihttp://hdl.handle.net/11040/23813
dc.description50 leaves : illustrations.en_US
dc.descriptionThesis--Departmental honors in Biochemistry.
dc.descriptionBibliography: leaves 49-50.
dc.description.abstract"The purpose of this study was to investigate the feasibility of using water for the synthesis of tyrosine analogues through asymmetric hydrogenation reactions. A variety of α-enamide substrates, varying in R groups and location on the benzene ring, were synthesized including methyl-2-(benzoylamino)-3-(p-butoxyphenyl)-propenoate, methyl-2-(benzoylamino)-3-(o-methoxyphenyl)-propenoate, and methyl-2-(benzoylamino)-3-(p-methoxyphenyl)-propenoate. These substrates were subsequently hydrogenated in water at 60 psi to produce methyl-2-(benzoylamino)-3-(p-methoxyphenyl)-propanoate, methyl-2-(benzoylamino)-3-(o-methoxyphenyl)-propanoate, and methyl-2-(benzoylamino)-3-(p-butoxyphenyl)-propanoate. These results confirmed that water can be used as the solvent for asymmetric hydrogenations of enamide ester materials to synthesize tyrosine analogues."en_US
dc.language.isoen_USen_US
dc.publisherWheaton College (Norton, Mass.)
dc.subjectUndergraduate research.
dc.subjectUndergraduate thesis.
dc.subject.lcshAsymmetric synthesis.
dc.subject.lcshTyrosine.
dc.subject.lcshEnamines -- Synthesis.
dc.subject.lcshAmino acids.
dc.subject.lcshHydrogenation.
dc.titleAsymmetric hydrogenation of tyrosine analogues in water.en_US
dc.typeThesisen_US


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