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dc.contributor.authorSholi, Adam N.
dc.date.accessioned2014-10-03T14:11:03Z
dc.date.available2014-10-03T14:11:03Z
dc.date.issued2014
dc.identifier.otherW Thesis 1460
dc.identifier.urihttp://hdl.handle.net/11040/23871
dc.description74 leaves : illustrations.en_US
dc.descriptionBibliography: leaves 71-74.
dc.description.abstractIn this study sea urchin embryos were used to investigate how cilia are disassembled and to investigate the role that cilia play in cell division. A retraction mechanism was proposed in which the ciliary axoneme is entirely withdrawn into the cell cytoplasm before it is completely disassembled. This mechanism may be mediated by a cortically-localized, plus-end directed motor protein. To determine biochemical distributions of the axoneme and mitotic spindle, a ratiometric imaging technique was developed. Analysis of ratiometric images suggests that the axoneme is destabilized by a deacetylase enzyme which may function to regulate the levels of alpha-tubulin and acetylated tubulin present in the mitotic spindle. The use of ratiometric imaging will be useful for future experiments that investigate the role of other post-translational modifications to tubulin. This study reports the identification of two distinct retraction modes which appear to be independent of cilia subtype or length.en_US
dc.language.isoen_USen_US
dc.publisherWheaton College (Norton, Mass.)en_US
dc.subjectUndergraduate research.
dc.subjectUndergraduate thesis.
dc.subject.lcshCilia and ciliary motion.
dc.subject.lcshCell division.
dc.subject.lcshGenetic disorders.
dc.subject.lcshEchinoida -- Embryos -- Genetics.
dc.subject.lcshSea urchins -- Embryos -- Genetics.
dc.subject.meshCiliary Motility Disorders.
dc.titlePatterns of ciliary retraction in echinoid embryos.en_US
dc.typeThesisen_US


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