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dc.contributor.authorSoucier, Devon.
dc.date.accessioned2014-10-03T14:41:26Z
dc.date.available2014-10-03T14:41:26Z
dc.date.issued2014
dc.identifier.otherW Thesis 1463
dc.identifier.urihttp://hdl.handle.net/11040/23873
dc.description57 leaves : illustrations.en_US
dc.descriptionBibliography: leaves 56-57.
dc.description.abstractToll-like receptors (TLRs) are a multigene family whose function is critical to the innate immune system in invertebrates and vertebrates. Variation within TLR gene regions may be a reflection of environment and pathogen co-evolution. The purpose of this study is to evaluate the level of genomic variation at TLR 5, 9, and 21 of Atlantic killifish Fundulus heteroclitus. Atlantic killifish have been studied extensively because of their ability to survive in variable environments that may be breeding grounds for varying populations of pathogens. The study looked at four populations of killifish from northern Maine. Sites included one copper contaminated locale and three other presumably uncontaminated environments. Average heterozygosity was calculated for all individuals at the gene regions. The results suggested that little variation was evident in the exon region of TLR 5. However, more variation was seen at the exon regions of TLR 9 and 21, as well as, the 5'UTR of TLR 9. Variation amongst the four populations was also detected. These results suggest that variation does exist at TLR 5, 9, and 21, however further studies need to be completed in order to gauge the implications of this variation.en_US
dc.language.isoen_USen_US
dc.publisherWheaton College (Norton, Mass.)en_US
dc.subjectUndergraduate research.
dc.subjectUndergraduate thesis.
dc.subject.lcshKillifishes -- Immunology -- Genetic aspects.
dc.subject.lcshKillifishes -- Variation -- Maine.
dc.subject.lcshKillifishes -- Maine -- Genetic aspects.
dc.subject.lcshKillifishes -- Effect of water pollution on.
dc.subject.lcshVariation (Biology)
dc.subject.lcshMolecular population biology.
dc.titleEvidence for selection of toll-like receptors in Atlantic killifish Fundulus heteroclitus.en_US
dc.typeThesisen_US


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