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dc.contributor.authorBartolotta, Myah
dc.date.accessioned2019-04-15T12:43:38Z
dc.date.available2019-04-15T12:43:38Z
dc.date.issued2018
dc.identifier.otherW Thesis 1537
dc.identifier.urihttp://hdl.handle.net/11040/24544
dc.descriptioni, 59 leaves; illustrations.
dc.descriptionIncludes bibliographical references: leaves 35-36.
dc.description.abstractThis study analyses the effects of pH and temperature on cyclodextrin-fluorouracil and cyclodextrin-uracil complexes. Fluorouracil is a chemotherapy drug given in high dosages leading to severe adverse effects. To reduce the severity of these effects, the drug would need to be more water soluble increasing the efficacy of the drug. To increase the water solubility, a host molecule cyclodextrin is used to form an inclusion complex with the drug. The thermodynamic properties and chemical equilibria were determined of different pH and temperature environments to gain a better understanding of this complex formation. It was found that the reaction between the host-guest molecules is a spontaneous process, endothermic, and entropy- driven. As the temperature increases, the number of host-guest molecules increase.en_US
dc.description.tableofcontents1.Introduction – 1.1 General host-guest chemistry background – 1.2 Cyclodextrins – 1.2a General structure – 1.2b Complex formation –1.2c Solubility – 1.2d Advantages of using cyclodextrin as a host molecule –1.2e Applications –1.3 General biochemistry – 1.3a Structure of DNA – 1.3b DNA replication –1.4 5-Fluorouracil – 1.4a Structure and chemical properties –1.4b Function as a chemotherapy drug –1.5 Binding constants – 1.6 Goal of experiment 2. Experimental procedures – 2.1 Materials – 2.2 Methods and instrumentation –2.2a FT-IR spectroscopy – 2.2b Preparation of stock solutions -- 2.2c Preparation of samples – 2.2d Measuring absorption spectra – 2.2e Measuring emission spectra – 3. Results and discussion – 3.1 Infrared spectroscopy – 3.2 Absorption and emission spectra; data analysis – 4. Limitations – 5. Future work – 6. References
dc.language.isoen_USen_US
dc.publisherWheaton College (MA).en_US
dc.subjectUndergraduate research.
dc.subjectUndergraduate thesis.
dc.subject.lcshFluorouracil.
dc.subject.lcshSupramolecular chemistry.
dc.subject.lcshBiochemistry.
dc.subject.lcshCyclodextrins.
dc.titleTemperature and pH effects on the formation of cyclodextrin-fluorouracil and cyclodextrin-uracil complexes.en_US
dc.title.alternativeTemperature and pH effects on the formation of cyclodextrin-fluorouracil.en_US
dc.typeThesisen_US


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