Mechanochemical Synthesis of Thiolactams with Lawesson's Reagent

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Authors
Goodwin, Matthew
Issue Date
2021-05-16
Type
Thesis
Language
en_US
Keywords
Undergraduate research. , Undergraduate thesis. , Thiolactam. , Lawesson's Reagent.
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Abstract
Thiolactams have proved to be an essential class of compounds in medicine, agriculture, and chemical synthesis. These compounds can be reliably synthesized with 2,4-bis(4- methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-dithione a thionation reagent that has widely become known as Lawesson's reagent (LR). In this study mechanochemistry, a new subfield of solid-state chemical synthesis which has proven useful because of its environmentally friendly nature and highly optimizable reaction conditions is used to develop the first known mechanochemical synthesis with Lawesson's reagent to produce thiolactams ring sizes 5 through 8.
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32 pages, illustrations
Citation
Goodwin, Matthew D. (2021, May 16). Mechanochemical Synthesis of Thiolactams with Lawesson's Reagent
Publisher
Wheaton College. (Norton, Mass.)
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